杆菌感染对眼睛表面的双重影响:眼分泌的破坏和眼睛表面微生物组的改变
Yinjie Guo1,2,3,4, Jiahui Lin5, Hao Wu6
1Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Investigative ophthalmology & visual science
|October 27, 2025
概括
杆菌感染显著恶化干眼症状,并改变眼睛的微生物群. 这可能通过炎症和T淋巴细胞透到眼腺发生,导致干眼疾病.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 杆菌 (H. pylori) 是一种已知会引起胃肠道问题的细菌.
- 它在干眼等眼睛表面疾病中的潜在作用尚不清楚.
研究的目的:
- 为了研究H. pylori感染对眼睛表面平衡的影响.
- 这包括评估干眼症状,眼球微生物群和免疫反应.
主要方法:
- 人体受试者:31名H.pylori阳性 (Hp_pos) 和30名H.pylori阴性 (Hp_neg) 个体接受了干眼评估.
- 使用16S rRNA测序分析了眼睛的微生物群.
- 用一种小鼠H. pylori感染模型来评估眼睛干燥和眼腺中的免疫反应.
主要成果:
- Hp_pos受试者表现出减少的眼分泌 (Schirmer I测试) 和眼破裂时间 (NIKf-BUTs,NIKav-BUTs),眼睛表面疾病指数 (OSDI) 分数更高.
- 在Hp_pos受试者中,眼表面微生物群的多样性发生了变化,特定的属性得到了丰富.
- 受感染的小鼠在感染后6周表现出水性眼缺乏,角膜屏障受损,眼腺炎症和高水平的炎症前导细胞因子.
结论:
- 杆菌感染会破坏水分泌,并改变眼睛表面的微生物群.
- 感染可能通过诱导T淋巴细胞透和眼腺炎症,导致干眼病原体.
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