药物输送和hesperidin的配方开发:一个系统的审查
Thi Phuong Nga Hoang1, Peter Timmins1, Alan M Smith1
1Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
Expert opinion on drug delivery
|October 27, 2025
概括
配方策略显著增强西的作用.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 自然产品化学 自然产品化学
背景情况:
- 素是类植物中的天然生物黄,具有强大的抗氧化,抗炎,抗癌和神经保护性质.
- 赫斯佩里丁的临床使用受到溶解性差,生物可用性低以及稳定性挑战的阻碍.
研究的目的:
- 系统地审查旨在改善hesperidin生物制药性质的配方策略.
- 确定领先的配方方法及其对赫斯佩里丁生物可用性和治疗潜力的影响.
主要方法:
- 在主要的科学数据库 (PubMed,MEDLINE,Scopus,Google Scholar) 中按照PRISMA指南进行系统的文献搜索,截至2025年1月10日.
- 包括专注于素配方和报告生物制药或生物结果的原始研究.
- 独立选,数据提取,以及由两名审稿人进行偏差风险评估.
主要成果:
- 69项研究符合资格标准,评估了各种配方平台,包括包容复合物,固体分散,SMEDDS,微粒,凝和各种纳米配方.
- 大多数配方改善了hesperidin的溶解和/或暴露.
- 脂质和聚合物纳米系统表现出最显著和最一致的改善,在血管,代谢和瘤指标方面有前途的早期临床数据.
结论:
- 先进的配方,特别是基于脂质的系统,聚合物纳米粒子和植物体,可以有效地克服hesperidin的生物制药限制.
- 未来的翻译需要强大的稳定性和免疫毒性数据,质量设计制造和经过精心设计的临床试验,具有标准化的终点.
相关概念视频
01:16Drug Delivery: Overview
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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01:27Bioavailability Enhancement: Drug Permeability Enhancement
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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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01:22Drug Delivery: Miscellaneous Routes
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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01:18Drug Delivery: Enteral Route
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
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01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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