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铁素-2,系统性免疫-炎症指数和性心肌病中短期不良心血管事件之间的关系

Yafei Zhang¹, Dahe Han², Chun Yang³

¹Department of Critical Care, Xuzhou Mining Group General Hospital (The Second Affiliated Hospital of Xuzhou Medical University), Xuzhou, China. YafeiZhangZhang@hotmail.com.

Iranian journal of allergy, asthma, and immunology

|October 27, 2025

概括

提升的 thioredoxin-2 (Trx-2) 和全身免疫炎症指数 (SII) 在败血性心肌病 (SCM) 中预测主要不良心脏事件 (MACE). 较高的Trx-2和SII水平表明SCM患者的短期MACE风险增加.

科学领域:

心脏病学心脏病学
关键护理医学关键护理医学
生物标志物生物标志物

背景情况:

败血性心肌病 (SCM) 是败血症的严重并发症,与心脏功能障碍和死亡率的增加有关.
确定可靠的生物标志物来预测SCM患者的短期主要不良心脏事件 (MACE) 对于及时干预至关重要.

研究的目的:

为了研究血清硫素-2 (Trx-2) 水平,全身免疫炎症指数 (SII) 和SCM患者短期MACE的发病率之间的关联.

主要方法:

一项回顾性研究包括98名SCM患者,根据28天的结果分为MACE和非MACE组.
使用后勤回归和受限立方线模型来分析SII,Trx-2和MACE风险之间的关系.
接收机运行特征 (ROC) 曲线分析评估了SII和Trx-2的预测性能,单独和组合.

主要成果:

血清SII和Trx-2水平升高与SCM患者28天MACE风险增加显著相关.
在增加SII或Trx-2水平和短期MACE风险之间观察到线性剂量反应关系.
SII和Trx-2的组合显示了MACE的高预测值 (AUC=0.926),表现优于单个标志物.

结论:

血清SII和Trx-2的异常增加与SCM中短期MACE发生有关.
血清SII和Trx-2作为SCM患者短期MACE的有价值的预测生物标志物.
监测SII和Trx-2水平可以帮助SCM的风险分层和管理.

关键词:

心肌病是一种心肌病.心血管疾病的心血管疾病.中性粒细胞中性粒细胞.污水污道是什么意思?类毒素 (thioredoxins) 是一种类毒素.

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