电针治疗结直肠癌中化疗诱导的胃肠道症状:多中心,三臂,随机对照试验的协议
Zi-Wen Chen1,2, Tao Xu3, Zi-Han Yin1,2
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
International journal of colorectal disease
|October 27, 2025
概括
电针 (EA) 可以有效地减少结直肠癌 (CRC) 患者的化疗诱导的胃肠道 (GI) 毒性. 本研究研究EA作为一种非药物治疗方法来改善生活质量和化疗坚持.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 综合医学是一个整体的医学.
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 化学治疗常常导致严重的胃肠道 (GI) 毒性,影响患者的生活质量.
- 缺乏有效的非药物干预方法来治疗化疗引起的胃肠道症状.
研究的目的:
- 评估电针 (EA) 在缓解化学疗法诱导的肠胃功能障碍中对CRC患者的疗效.
- 评估EA作为标准癌症治疗的安全,非药物补充剂的潜力.
主要方法:
- 一个多中心,三臂随机受控试验 (RCT) 涉及231名CRC患者,患有化疗后的胃肠道症状.
- 干预包括电针 (EA) 加标准护理,假针 (SA) 加标准护理,或单独标准护理.
- 主要结果:胃肠道症状评分表 (GSRS) 总分数的变化;次要结果:GSRS分量表,FACT-C,SAS/SDS分数.
主要成果:
- 这个部分不在所提供的摘要中.
- 该研究旨在产生关于EA有效性的高质量证据.
- 结果将使用意图治疗线性混合效应模型进行分析.
结论:
- 电针 (EA) 显示出作为一种非药物干预的承诺,用于治疗结直肠癌 (CRC) 患者的化疗诱导的肠道毒性.
- 如果有效,EA可以减少症状负担并改善患者对化疗的坚持.
- 本RCT旨在提供强有力的证据,用于将EA纳入标准CRC护理中.
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