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通过Geant4-DNA量化来自目标α发射体225Ac和227Th的DNA链断裂:对RBE和细胞存活的影响

Samaneh Zolghadri¹, Payman Rafiepour², Hassan Yousefnia³

¹Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, 14155-1339, Iran. szolghadri@aeoi.org.ir.

|October 27, 2025

概括

使用Actinium-225和Thorium-227的向alpha疗法通过诱导显著的DNA损伤,显示出癌症治疗的前景. 这些放射性核酸具有很高的有效性,这表明它们有可能改善治疗结果.

科学领域:

核医学就是核医学.
辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

向性阿尔法疗法 (TAT) 使用高线性能量转移 (LET) 的阿尔法粒子来治疗癌症.
像-225 (Ac) 和-227 (Th) 这样的放射性核酸会诱导密集的局部DNA损伤.

研究的目的:

使用Geant4-DNA模拟由225Ac和227Th诱导的DNA损伤.
评估这些α发射器的放射生物效应和相对生物有效性 (RBE).

主要方法:

使用Geant4-DNA工具包进行蒙特卡洛模拟.
对DNA损伤模式的分析,包括复杂的双链断裂 (DSB).
细胞存活分析以评估生物影响.

主要成果:

无论是225Ac和227Th都会诱导显著的DNA损伤,而227Th会导致更集群的损伤.
观察到两种放射性核素的RBE升高,特别是复杂的DSBs.
细胞活力急剧下降,与诱导的集群DNA损伤相关.

结论:

225Ac和227Th显示了针对性放射性核素治疗的巨大潜力,特别是在耐药瘤中.
高RBE和复杂的DNA损伤表明,当与其他疗法相结合时,疗效提高.
这些发现支持优化TAT协议和Ac和Th的临床翻译.

关键词:

225AcAc225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac2 227ThTh 这是一本书.细胞存活率细胞存活率造成的DNA损伤是DNA损伤.在GEANT4-DNA中.相对生物有效性相对生物有效性有针对性的阿尔法疗法

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