促炎症饮食与中年和老年人大脑年龄之间的关联
Michelle M Dunk1,2, Huijie Huang3, Jiao Wang4,5
1Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Tomtebodavägen 18A, Floor 10, 171 65, Stockholm, Sweden. michelle.dunk@ki.se.
European journal of epidemiology
|October 27, 2025
概括
支持炎症的饮食加速大脑衰老,特别是在老年人中. 这种饮食模式与生物学上较老的大脑有关,独立于痴呆的遗传风险.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 促炎症饮食与认知衰退和痴呆症有关.
- 饮食对大脑衰老的具体影响尚不清楚.
- 了解饮食对大脑衰老的作用对于预防策略至关重要.
研究的目的:
- 为了研究促进炎症饮食和大脑年龄之间的关联.
- 检查年龄,遗传风险和全身炎症对这种关系的影响.
- 为了确定饮食是否会影响大脑老化,超出时间表年龄.
主要方法:
- 利用了来自21473名参与者 (年龄在40-70岁) 的英国生物库数据.
- 从通过24小时回忆的营养摄入量计算的饮食炎症指数 (DII).
- 在MRI数据上使用机器学习估计的大脑年龄,计算大脑年龄差距 (BAG).
- 评估了阿尔茨海默氏症多基因风险评分 (PRS_AD),APOE4状态和全身炎症 (INFLA-score).
主要成果:
- 较高的DII分数 (更多的促炎饮食) 与BAG的增加相关.
- 具有最有利于炎症的饮食的参与者表现出先进的大脑衰老.
- 在60岁及以上的成年人中,相关性更强.
- 系统性炎症部分调解了饮食与大脑年龄的关联.
结论:
- 支持炎症的饮食可能会加速大脑衰老.
- 这种效应在老年人中更为明显.
- 饮食干预可以成为缓解与年龄相关的大脑变化的目标.
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