乳腺癌血管生成的微环境调节和重塑:从基本机制到临床治疗影响
Ziling Zhou1, Hanyi Zhong1, Han Wang1
1Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai, 200025, China.
Discover oncology
|October 27, 2025
概括
新的血管形成 (血管生成) 推动乳腺癌 (BC) 的生长和扩散. 针对这一过程需要了解瘤微环境 (TME),而不仅仅是VEGF,以克服治疗阻力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 瘤微环境研究 研究
背景情况:
- 血管新生对于乳腺癌 (BC) 的进展和转移至关重要.
- 血管内皮生长因子 (VEGF) 途径是关键驱动因素,但抗VEGF治疗的耐药性是一个重大的临床挑战.
- 瘤微环境 (TME),包括缺氧,代谢变化和树突细胞 (纤维细胞,脂肪细胞,免疫细胞),在调节血管生成和治疗耐药性方面发挥着复杂的作用.
研究的目的:
- 综合有关乳腺癌血管生成多方面的调节的新兴证据.
- 讨论针对血管生成和TME组件的创新治疗策略.
- 突出临床试验和转化机会,以改善BC结果.
主要方法:
- 文献综述综合了当前关于BC血管生成的研究.
- 分析内皮细胞,皮质细胞,免疫细胞和树皮组成部分的作用.
- 讨论治疗策略,包括低氧向药物,免疫调节和组合疗法.
主要成果:
- 在BC中异常血管生成是由TME内部的复杂相互作用驱动的,涉及缺氧,代谢重编程和各种树皮细胞.
- 对抗VEGF治疗的耐药性与替代的益血管性通路和TME组件有关.
- 重塑TME的综合治疗方法对于克服抵抗至关重要.
结论:
- 有效的乳腺癌治疗需要解决TME对血管生成的复杂调节的策略.
- 组合疗法和低氧向药物显示出有希望的结果.
- 需要进一步的研究和临床试验,以将这些发现转化为改善患者的治疗结果和减少转移.
更多相关视频
09:03Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
10.1K
09:03Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
Published on: June 30, 2023
1.6K
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
02:17The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
01:10Mechanism of Angiogenesis
6.7K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.7K
02:53Adaptive Mechanisms in Cancer Cells
6.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.9K