用于将抗微生物耐药性考虑纳入肺炎球菌结合疫苗经济模型的概念方法框架
Mark H Rozenbaum1, Maria J Tort2, Ruth Chapman3
1Pfizer Inc., Collegeville, PA, USA. Mark.Rozenbaum@pfizer.com.
Infectious diseases and therapy
|October 27, 2025
概括
肺炎球菌联合疫苗 (PCV) 显著减少了抗生素处方和耐药感染. 一个简化的框架有效地模拟了这些影响,强调了疫苗在打击抗菌素耐药性 (AMR) 中的关键作用.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 卫生经济学 卫生经济学
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球重大健康和经济挑战.
- 疫苗是减少抗生素使用和预防耐药感染的重要工具,从而打击AMR.
- 当前的经济分析往往低估了疫苗的好处,并没有考虑其对AMR的影响.
研究的目的:
- 构思一个框架来估计疫苗接种对AMR的影响.
- 使用肺炎球菌结合疫苗 (PCV) 作为本框架的案例研究.
- 为了证明在疫苗经济评估中包括AMR影响的重要性.
主要方法:
- 制定了三条路径框架:人口和病原体,护理和健康结果.
- 承认数据的局限性,并使用现有的抗生素处方和耐药性数据采用简化模型.
- 利用现有数据来估计与AMR相关的关键结果的影响.
主要成果:
- 与PCV13相比,常规PCV20疫苗接种预计将在25年内预防超过2300万份抗生素处方和1400万例抗药性感染.
- 与PCV15相比,PCV20估计可以预防超过1200万份抗生素处方和700万种耐药性感染.
- 这些发现凸显了婴儿PCV免疫对减少AMR病例和抗生素使用的重大影响.
结论:
- 一个简化的模型有效地结合了AMR参数,用于全面的PCV评估.
- 该框架确定了未来研究和建模工作的关键数据缺口.
- 疫苗影响评估必须包括AMR,以充分把握健康和经济效益.
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