孕产妇肥胖计划 怀孕女性后代的葡萄糖不耐受
Liping Qiao1, Cindy Lu1, Sarah Saget1
1Department of Pediatrics, University of California San Diego, La Jolla, CA.
Diabetes
|October 27, 2025
概括
在小鼠中,孕产妇的肥胖导致雌性后代的妊娠代谢受损,导致胰岛素缺乏和脂质稳定性受损. 这可能会造成代谢功能障碍的跨代周期,增加未来几代人面临的风险.
科学领域:
- 代谢健康 代谢健康
- 生殖生物学 生殖生物学
- 健康和疾病的发育起源
背景情况:
- 孕产妇的肥胖是后代代谢功能障碍的重要危险因素.
- 孕产妇肥胖对雌性后代代代谢适应怀孕的具体影响尚不清楚.
研究的目的:
- 调查高脂肪 (HF) 饮食引起的母性肥胖对雌性后代对怀孕的代谢适应的影响.
- 探索对代谢健康的潜在跨代影响.
主要方法:
- 利用小鼠模型 (C57BL/6J),在怀孕前和怀孕期间,母鼠被食高脂肪 (HF) 饮食或控制食饮食.
- 在女性后代怀孕期间评估胎儿生长,产后发育,成人脂肪和代谢参数 (葡萄糖,胰岛素,甘油三) .
- 检查了来自孕妇后代的培养小岛的葡萄糖刺激胰岛素分泌和β细胞功能.
主要成果:
- 高频养母 (OF-HFD) 的雌性后代显示胎儿生长减少,随后是追赶生长和增加成人脂肪.
- 在怀孕期间,OF-HFD表现出代谢适应障碍,包括体脂肪和甘油三酸的增加减少,葡萄糖不耐受,尽管正常的β细胞质量减少了胰岛素分泌.
- 在孕妇OF-HFD中,肝脏甘油三分泌量减少,肝脏胰岛素信号增强,表明脂质和葡萄糖代谢发生改变.
结论:
- 孕产妇的肥胖严重损害了雌性后代对怀孕的代谢适应,导致胰岛素缺乏和脂质稳定性受损.
- 雌性后代的这些代谢变化可能会导致代谢功能障碍的跨代周期,可能会增加妊娠糖尿病的风险.
- 研究结果强调,需要进行干预措施,以缓解跨代孕孕产妇肥胖的长期代谢后果.
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