在诱导全身麻醉期间,在预防剂量以弗得林,上腺素,上腺素和安慰剂后的血液动力学变化:一项随机试验
Gunnar Helge Sjøen1,2,3, Tor Hugo Hauge4, Ragnhild Sørum Falk5
1Department of Anaesthesiology, Fonna Hospital Trust, Haugesund, Norway.
预防性埃弗德林在麻醉诱导期间有效地维持了血压和心率. 上腺素和上腺素表现出类似于安慰剂的短期作用,使得以弗德林成为推的玻尿酸剂的最佳选择.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 心血管生理学心血管生理学
背景情况:
- 在麻醉诱导期间的低血压通常使用诸如乙氨酸,氨酸和上腺素之类的血管压缩剂来控制.
- 这项研究评估了预防性血管压缩剂在维持血液动力学稳定的有效性.
研究的目的:
- 为了比较预防性以弗得林,乙烯和上腺素对静脉静脉血压 (SAP) 和心率 (HR) 后麻醉诱导的作用.
- 为了确定这些血管压缩剂是否能在最初的5分钟内保持SAP和HR在基线的80%以内.
主要方法:
- 一项随机,双盲,剂量控制的研究,涉及128名接受妇科手术的健康女性.
- 参与者在用普罗波福和雷米芬坦尼尔诱导麻醉之前接受了预防性埃弗德林,乙烯,上腺素或安慰剂.
- 节奏对节奏的血液动力学监测评估了SAP,HR,中风体积 (SV),心脏输出 (CO) 和全身血管阻力 (SVR) 的变化.
主要成果:
- 乙有效地维持了SAP,HR和CO,相对减少了20%的SAP,-17%的HR和-22%的CO.
- 上腺素和上腺素的作用时间有限,在5分钟内,SAP与安慰剂相当.
- 上腺素的相对降低为-30%的SAP,-30%HR和-38%的CO;对于诺亚上腺素,-30%的SAP,-37%HR和-42%的CO.
结论:
- 建议在麻醉诱导期间进行预防性乙二醇施用,以保持血液动力学稳定性.
- 上腺素和上腺素玻尿酸注射证明了短期有效性,在服用后5分钟内没有证明比安慰剂优越.
- 当预防性血管压缩剂被指示时,以弗得林与上腺素或上腺素相比,提供了有利的概况.
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