在生育年龄期间被诊断患有癌症的妇女生育
Giovanna Esposito1,2, Anna Cantarutti3,4, Matteo Franchi3,4
1Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy.
Acta obstetricia et gynecologica Scandinavica
|October 27, 2025
概括
在生育年龄的妇女中,癌症诊断显著降低了生育概率,特别是在诊断后5年内和30岁之后. 抗瘤疗法进一步降低了出生率,但增加了医疗辅助生殖的使用.
科学领域:
- 生殖医学 生殖医学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 癌症后的生育能力是妇女在生育年龄被诊断为癌症的一个重大临床问题.
- 这项研究调查了2012-2017年间在意大利伦巴第省被诊断患有癌症的妇女的生育结果.
研究的目的:
- 评估和比较在生育年龄被诊断患有癌症的妇女与无癌症对照群的生育结果.
- 确定影响生育能力的因素,如诊断时的年龄和抗瘤治疗.
主要方法:
- 使用区域医疗保健数据库进行匹配的队列研究 (13,877名患有癌症的妇女,匹配对照).
- 累积发病率函数和考克斯回归模型用于估计分娩概率和危险比率.
- 逻辑双项回归以评估抗瘤疗法与医疗辅助生殖之间的关联.
主要成果:
- 与对照组相比,患有癌症的女性在所有年龄组中都显示出分娩的累积概率降低.
- 在诊断后5年内,这种可能性的减少是显著的,特别是在30岁后被诊断出来的人中.
- 抗瘤治疗与后期分娩的可能性较低 (HR=0.46),但医疗辅助生殖的可能性更高 (RR=1.71).
结论:
- 在癌症诊断后5年内,无论年龄如何,生育概率显著降低.
- 诊断时的年龄 (特别是30岁以上) 和抗瘤疗法是影响生育结果的关键因素.
- 研究结果强调了需要生育保护策略和支持癌症幸存者的必要性.
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