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Updated: Jun 6, 2026

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging
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在一个工程化利波卡林蛋白中进行的 conformational quenching 实现了对毒素colchicine的高 afinity 结合

Mark J Bostock1,2, Christopher Kolloff3, Elena Jerschke4

  • 1Bavarian NMR Center and Department of Bioscience, TUM School of Natural Sciences, Technical University of Munich, 85748, Garching, Germany.

Angewandte Chemie (International ed. in English)
|October 27, 2025
PubMed
概括

工程Colchicalin蛋白质与高亲和力结合了. 蛋白质动力学,特别是循环重新排列,对于这种高亲和度结合至关重要,支持构造性选择机制.

关键词:
这是一种抗素的抗素.符合性选择的选择.分子动力学分子动力学核磁共振光谱法 (NMR) 是一种光谱法.蛋白质动力学 蛋白质动力学

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Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...