将层次血管系统集成到工程心脏组织中
Richard Z Zhuang1, Francois Chesnais1, Gordana Vunjak-Novakovic1,2,3
1Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Advanced materials (Deerfield Beach, Fla.)
|October 27, 2025
概括
工程功能人类心脏组织需要整合血管. 本综述探讨了血管化心脏组织的生物和工程策略,强调了改进翻译的混合方法.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 将可 perfusable 血管系统集成到工程心脏组织中,是临床翻译的关键挑战.
- 目前的策略集中在细胞驱动的自我组织或生物制造引导的结构上,在结合两者方面取得的成功有限.
- 弥合心肌和血管组织工程之间的差距对于功能性心脏结构至关重要.
研究的目的:
- 审查和评估工程血管化心脏组织当前的策略.
- 将方法分为生物驱动和工程驱动的方法.
- 提出一个前进的道路,强调混合策略,以提高生理和翻译相关性.
主要方法:
- 将血管化策略分为生物驱动 (细胞自我组织) 和工程驱动 (生物制造) 的方法.
- 基于结构忠实性,功能成熟度和可扩展性的每个战略的评估.
- 开发一个基准测试框架,以评估生理和翻译相关性.
主要成果:
- 生物驱动的方法利用细胞内在的机制来形成血管网络.
- 工程驱动的方法采用生物制造技术来决定组织结构.
- 这两种方法在实现全面的血管化和功能整合方面都有局限性.
- 结合两种方法的混合策略显示出克服当前局限性的前景.
结论:
- 一种混合方法,将细胞驱动的自我组织与生物制造相结合,对于推进血管化的心脏组织工程至关重要.
- 需要进一步的研究来优化混合战略,以改善结构完整性,功能成熟和可扩展性.
- 解决血管整合的挑战是翻译工程心脏组织用于治疗应用的关键.
相关概念视频
Overview of the Cardiovascular System
15.4K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
15.4K
Overview of the Heart
32.2K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
The heart's structure...
32.2K
Layers of the Heart Wall
7.2K
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
7.2K
Heart Valves
14.9K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
14.9K
Development of the Heart
3.9K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
3.9K
Development of Blood Vessels
2.0K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
2.0K


