耐药病原体和移动遗传元素的驱动的选择加剧了饮用水处理中的抗生素耐药性风险
Dan Guan1, Chunjing Chen1, Yuhong Zheng1
1Department of Environment Health, Nanjing Municipal Center for Disease Control and Prevention, Nanjing 210003, China.
Ecotoxicology and environmental safety
|October 27, 2025
概括
饮用水消毒可以增加抗生素耐药性基因 (ARG) 并对病原体进行选择. 侵袭性化丰富了ARG和毒性因子,突出了水的生物安全风险.
科学领域:
- 环境微生物学环境微生物学
- 水处理技术水处理技术.
- 公共卫生 公共卫生
背景情况:
- 饮用水中的抗生素耐药性基因 (ARG) 对公众健康构成重大风险.
- 水处理过程,特别是消毒对病原体和ARG动态的影响尚未完全理解.
研究的目的:
- 为了比较两个饮用水处理列车 (PK和CX) 对微生物群落,病原体概况和ARG传播的影响.
- 研究化和移动遗传元素 (MGE) 在ARG丰富和传播中的作用.
主要方法:
- 用元基因组学分析来比较两个不同的饮用水处理列车 (PK和CX).
- 处理列车包括沙子过,臭氧化活性炭和不同度的NaClO (化).
- 分析的重点是微生物多样性,病原体识别,毒性因子,ARG和MGE.
主要成果:
- 化减少了微生物的α-多样性,但被选择用于特定的病原体,如沙门氏菌和大肠杆菌.
- 抗生素耐药性基因 (ARG),特别是多药耐药性基因 (MRG),在化后具有矛盾的丰富性.
- 移动遗传元素 (MGE),如IS91,与ARG传播有很强的相关性,高剂量的低化物放大了传播风险.
结论:
- 积极的消毒策略可以选择耐药性病原体并丰富毒性因素.
- 消毒促进了ARG通过MGEs传播,增加了与饮用水相关的风险.
- 优化消毒策略对于确保水的生物安全性和减轻ARG传播至关重要.
相关概念视频
00:57Antibiotic Selection
59.3K
Overview
59.3K
01:30Development of Antibiotic Resistance
1.3K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.3K
01:26Physical Methods for Controlling Microbial Growth: Radiation and Filtration
985
Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
985
01:28Gene Regulation in Microbial Communities: Quorum Sensing
506
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
506
01:31Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
01:28Biological Methods for Microbial Control
776
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
776