尼古丁消费和怀孕期间的叶酸缺乏:基于人口的横截面研究
Weiyi Huang1, Melissa B Harrell2, Robin L Page3
1Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston, Houston, TX, USA.
概括
孕妇吸烟者患叶酸缺乏症的几率几乎是两倍. 医疗保健提供者应对所有孕妇进行叶酸状况和烟草使用的查,优先考虑吸烟者进行干预.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 烟草吸烟和叶酸缺乏是已知的妊娠不良结果的危险因素.
- 怀孕期间吸烟和叶酸状况之间的特定关联需要进一步调查.
研究的目的:
- 调查美国孕妇的烟草吸烟和叶酸缺乏症之间的联系.
主要方法:
- 从国家健康和营养检查调查 (2003-2020) 的九个周期的数据分析.
- 吸烟状况由血清丁氨酸水平决定;叶酸缺乏症由世卫组织指导方针定义.
- 罗-斯科特测试和逻辑回归模型用于评估流行率和关联.
主要成果:
- 在非西班牙裔黑人妇女中观察到吸烟和红细胞 (RBC) 叶酸缺乏症的高患病率,教育程度较低.
- 怀孕的吸烟者显著增加了红细胞叶酸缺乏症的几率 (OR:1.87;95% CI:1.10,3.19).
- 在怀孕妇女中,活跃吸烟约占RBC叶酸缺乏症病例的3.6%.
结论:
- 吸烟与孕妇患叶酸缺乏症的风险增加有关.
- 建议对所有孕妇进行叶酸状况评估和查 (例如,RBC叶酸检测).
- 针对烟草使用和营养风险的综合战略至关重要,有针对性地对吸烟者进行查.
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