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Updated: Jun 19, 2026

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DCAF16招募向合剂的作用模式,可以选择性地降低BRD9的作用

Scott J Hughes1, Wojciech J Stec1, Colin T R Davies1

  • 1Amphista Therapeutics Ltd, Cambridge, UK.

Nature communications
|October 28, 2025
PubMed
概括

研究人员开发了有针对性的粘合剂,这是一种新的分子降解策略. 作为一种强大的降解剂,AMPTX-1选择性地将DCAF16招募到BRD9中,使得蛋白质在体外和体内都能降解.

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相关概念视频

Export of Misfolded Proteins out of the ER01:32

Export of Misfolded Proteins out of the ER

After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...