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Updated: Jan 14, 2026

Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion
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Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion

Published on: September 13, 2024

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三核酸重复扩张的机制由MutSβ-MutLγ和FAN1收缩

Issam Senoussi1,2, Valentina Mengoli1, Arianna Cerana3

  • 1Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland.

Nature communications
|October 28, 2025
PubMed
概括

这项研究揭示了DNA重复扩张是如何通过MutLγ (MLH1-MLH3) 和MutSβ (MSH2-MSH3) 蛋白活性引起亨廷顿病等疾病的. 它还显示了FAN1蛋白如何防止这些扩张,防止重复扩张病理.

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