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Updated: Jan 14, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
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从庞大的图书馆中无条形码的成功发现,由自动化小分子结构注释启用.

Edith van der Nol1,2, Nils Alexander Haupt3, Qing Qing Gao1

  • 1LACDR, Leiden University, Leiden, The Netherlands.

Nature communications
|October 28, 2025
PubMed
概括

一个新的自编码库 (SEL) 平台允许在没有DNA标签的情况下选数百万个分子. 这种药物发现工具可以识别FEN1等具有挑战性的目标的强有力的结合剂,从而推进早期研究.

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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