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非碳水化合物性治疗可以抵消empagliflozin诱导的糖尿病症
Jimmy Asiku1,2, Mugagga Kalyesubula1,3, Maya Ross1
1Institute of Animal Sciences, Agricultural Research Organization-Volcani Institute, Rishon LeZion, Israel.
Nutrition & diabetes
|October 28, 2025
概括
糖醇补充剂可以减轻与SGLT2抑制剂相关的糖尿病酸性症 (DKA) 风险. 这项研究发现,甘油可降低糖尿病羊的症和增强胰岛素治疗,这表明对DKA管理的潜在益处.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- -葡萄糖共运输体2抑制剂 (SGLT2i) 对糖尿病提供心脏代谢益处,但增加了糖尿病酸症 (DKA) 的风险.
- 通过糖醇支持的阿纳普勒索斯被研究为一种抵消SGLT2i诱导的症和DKA风险的策略.
研究的目的:
- 为了评估糖在减轻SGLT2抑制剂诱导的症中的有效性.
- 评估甘油在增强胰岛素介导严重糖尿病症解决的作用.
- 为了确定饮食糖醇补充剂是否可以降低SGLT2i治疗糖尿病患者的DKA风险.
主要方法:
- 胰岛素依赖性糖尿病和严重的高血糖症/超血症在使用阿洛克桑的绵羊中被诱导.
- 症是由部分胰岛素撤销和empagliflozin的管理引起的.
- 绵羊接受了静脉注射甘油,用于中度/重度症治疗或食甘油补充剂.
主要成果:
- 静脉注射甘油减少了28.5%的中度症,并增强了胰岛素对严重症的影响.
- 食糖醇抑制了empagliflozin诱导的血液β-基酸盐 (BHB) 的早晨升高.
- 糖提供了对低血糖的保护,并改善了能量状态.
结论:
- 糖的使用有效地减少了empagliflozin诱导的和低血糖症.
- 糖醇作为一种有益的胰岛素辅助剂,用于解决严重的糖尿病症.
- 饮食中的糖对糖尿病症的营养预防和管理有前途,特别是在SGLT2i治疗期间.
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