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通过DNAPKcs调节DNAPKcs增强ETS1稳定性,在三阴性乳腺癌中在化疗抵抗期间调节转录变化

Aiindrila Dhara1,2, Imlimaong Aier3, Souhadri Das1

  • 1Department of Biological Sciences, Bose Institute, Kolkata, West Bengal, India.

NPJ breast cancer
|October 28, 2025
PubMed
概括

三阴性乳腺癌 (TNBC) 耐药性是由ETS1蛋白稳定性驱动的,由DNAPKcs酸化增强. 用抑制剂向DNAPKcs降解了ETS1,促进了抗性TNBC细胞的亡.

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