只有肠道微生物组的选择和传播可以改变哺乳动物的行为
Taichi A Suzuki1,2, Akbuğa-Schön Tanja1, Jillian L Waters1
1Department of Microbiome Sciences, Max Planck Institute for Biology, Tübingen, Germany.
Nature communications
|October 28, 2025
概括
宿主行为,就像活动水平一样,可以通过肠道微生物组传输单独进化,独立于遗传变化. 这项研究表明,微生物组选择可以塑造哺乳动物的特征和进化.
科学领域:
- 微生物组研究的研究.
- 行为生态学 行为生态学
- 进化生物学是进化的生物学.
背景情况:
- 动物宿主和肠道微生物共存,微生物群落在宿主适应过程中发生变化.
- 微生物组影响宿主特征,包括新陈代谢和行为.
- 一个关键的问题是,在自然选择下,宿主特征是否可以在没有基因组改变的情况下通过微生物群传播.
研究的目的:
- 通过实验来确定宿主行为特征是否可以通过肠道微生物组进行选择和传播.
- 研究微生物组介导遗传在哺乳动物进化中的作用.
主要方法:
- 从野生来源的小鼠移植便微生物群到无细菌的接受者,以评估运动活动的传播能力.
- 四轮连续微生物组选择,将微生物组从低活性捐赠者转移到无菌的小鼠.
- 分析行为变化和识别相关的微生物和代谢因素.
主要成果:
- 发动机活动通过肠道微生物组被证实是可传播的.
- 一条选择线显示,在四轮微生物组转移过程中,运动能力显著下降.
- 减少的活性与增加的乳酸菌及其代谢物乳酸有关,仅此一代谢物就抑制了运动.
结论:
- 肠道微生物组的选择和传播可以独立于宿主基因组进化来塑造哺乳动物的行为.
- 微生物组介导的特征遗传在宿主生态和进化中发挥着重要作用.
- 特定的微生物,如乳酸菌及其代谢物,可以直接影响宿主的行为.
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