声化学增强的活性炭具有改善的口服可口性,用于有效的在实验室中对乙氨基进行排毒
Forough Riahimanesh1,2, Ahmad Alahabadi3, Mehdi Salari4,5
1Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Scientific reports
|October 28, 2025
概括
来自Calligonum comosum木材的新活性炭有效地去除了乙氨基 (APAP) 过量毒素. 这种口服排毒剂,当与食物混合时,保持高效率,为患者友好的治疗.
科学领域:
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
- 生物医学工程 生物医学工程
背景情况:
- 乙氨基 (APAP) 过量服用是药物诱导的肝损伤的主要原因.
- 迫切需要有效的口服解毒剂来管理APAP过量服用.
- 目前的治疗方法在给药或疗效方面可能存在局限性.
研究的目的:
- 从Calligonum comosum木材中开发一种新的活性炭 (UA-AChar),用于APAP排毒.
- 描述UA-AChar的吸附特性,用于APAP的去除.
- 评估将UA-AChar纳入可口口服配方的可行性.
主要方法:
- 活性炭 (UA-AChar) 是通过氨酸辅助的化学激活和超声波处理合成的.
- 材料的表征包括表面积,毛孔大小和功能组分析.
- 在各种pH值和度下评估了吸附效率,同温度 (Freundlich) 和动力学 (伪二阶) 对于APAP去除.
- UA-AChar被添加到酸奶,冰淋和蜂蜜中,以评估味道性和有效性.
主要成果:
- UA-AChar表现出高的特定表面积 (1531 m2/g) 和一个中孔结构.
- 高APAP去除效率 (89%在pH1.2下,86%在pH7.5下) 迅速实现 (15分钟内).
- 最大吸附能力为787.5毫克/克 (pH1.2),以及725毫克/克 (pH7.5).
- 吸附遵循弗洛伊德利希等温和和伪二阶动力学.
- 将其纳入食品矩阵导致吸附效率最小降低 (<7%).
结论:
- UA-AChar 是一种高度有效的乙氨基吸收剂.
- 该材料的性能非常适合于口腔排毒应用.
- 与食物一起配制UA-AChar可以提高口感,而不会影响疗效,为APAP过量治疗提供了一个有希望的患者友好的治疗选择.
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