三糖-葡萄糖指数的变化以及因任何原因和心血管疾病死亡的风险
Jimin Park1, Duk Ho Kim2, Jun-Hyuk Lee3
1Department of Medicine, Eulji University School of Medicine, Daejeon, Republic of Korea.
Scientific reports
|October 28, 2025
概括
胰岛素抵抗的标志物甘油三糖 (TyG) 指数的更高变化与因所有原因和心血管疾病死亡风险的增加有关. 监测TyG指数变化可能有助于降低死亡风险.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 公共卫生 公共卫生
背景情况:
- 三甘油-葡萄糖 (TyG) 指数是胰岛素抵抗和心血管风险的验证指标.
- 已知代谢变异性会影响心血管结果,但TyG指数变异性对死亡率的影响尚不清楚.
研究的目的:
- 调查甘油三糖指数 (TyG) 变化与所有原因和心血管死亡风险之间的关联.
- 为了确定增加的TyG指数变化是否独立预测死亡风险.
主要方法:
- 从国家健康查计划 (2009-2014) 中对3,094,062名个人进行了回顾性队列研究.
- 独立于平均值 (VIM) 的TyG指数可变性的计算和分类为四分位数.
- 考克斯比例危险回归分析以评估死亡风险.
主要成果:
- 在平均9.1年的随访期间,发生了137339例死亡 (4.44%),其中15261例 (0.56%) 是由心血管原因引起的.
- 死亡风险随着TyG指数VIM的四分位数较高而逐渐增加.
- 与最低四分位数相比,TyG指数变化的最高四分位数显示所有原因 (HR 1.18) 和心血管死亡率 (HR 1.13) 的风险明显更高.
结论:
- 增加的甘油三糖 (TyG) 指数变化与所有原因和心血管死亡率的风险增加有显著联系.
- 对TyG指数波动的连续监测可能有助于早期检测和干预,可能降低死亡率.
- 这些发现强调了评估超出心血管风险分层的平均水平的代谢变异性的重要性.
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