在人类结核病的进展过程中,外周血液细胞动态
Shanshan Zhu1, Qiuchen Dai2,3, Kai Wang2,3
1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, China. 230198597@seu.edu.cn.
Scientific reports
|October 28, 2025
概括
周围血液免疫细胞的早期变化,特别是自然杀手 (NK) 细胞,信号结核病 (TB) 的进展. 这些生物标志物可以帮助识别需要预防结核病干预的个体.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 结核病 (TB) 是一个重要的全球卫生问题.
- 周围血液免疫细胞的组成为结核病提供了洞察力.
- 了解免疫动态对于结核病管理至关重要.
研究的目的:
- 分析整个结核病谱的周围血液免疫细胞动态.
- 为了确定结核病进展的早期免疫生物标志物.
- 探索影响结核病免疫反应的因素.
主要方法:
- 对43个全球转录基因数据集的分析.
- 包括5902个外周血液样本.
- 检查从潜伏感染到活跃结核病和治疗的细胞动态.
主要成果:
- 早期结核病进展显示自然杀手 (NK) 细胞减少,单细胞增加.
- 亚临床结核病表现出进一步的NK和B细胞减少,单细胞增加.
- 活性结核病的特点是单细胞/中性粒细胞高,淋巴细胞低;治疗导致正常化.
- 免疫反应因结核病负担,年龄和艾滋病毒同时感染而有所不同.
结论:
- 周围血液免疫细胞的变化,特别是NK细胞的变化,是结核病进展的早期指标.
- 这些早期生物标志物可以作为预防性结核病干预的目标.
- 细胞动态提供了对结核病原和治疗反应的全面了解.
相关概念视频
Pulmonary Tuberculosis II
1.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.4K
Pulmonary Tuberculosis I
820
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
820
Pulmonary Tuberculosis III
921
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
921
Pulmonary Tuberculosis IV
472
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
472
Pulmonary Tuberculosis V
532
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
532


