一个完整的生命周期生物钟,基于常规临床数据及其对健康和疾病的影响
Kai Wang1,2,3, Fei Liu4,5, Wei Wu2,3
1Department of General Surgery, Department of Hepatobiliary Surgery, Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Zhejiang-Germany Interdisciplinary Joint Laboratory of Hepatobiliary-Pancreatic Tumor and Bioengineering, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Nature medicine
|October 28, 2025
概括
使用电子健康记录,LifeClock可以预测从婴儿到老年的生物年龄. 这种新模型将儿科发育与成人衰老区分开来,改善了整个生命周期的疾病风险预测.
科学领域:
- 生物医学信息学 生物医学信息学
- 老年学是一门学科.
- 儿科 儿科 儿科
背景情况:
- 衰老研究主要集中在成人衰老上,忽视了童年和婴儿期的生物钟.
- 对于个性化的健康策略来说,全面了解整个生命周期的生物年龄至关重要.
研究的目的:
- 介绍LifeClock,一种新的生物钟模型,可以预测从婴儿期到老年期的生物年龄.
- 利用常规的电子健康记录和实验室数据进行精确的,个性化的年龄预测.
- 区分儿科发育与成人衰老模式及其相关疾病风险.
主要方法:
- 开发了LifeClock,一种利用时间序列变压器 (EHRFormer) 的生物年龄预测模型.
- 整合了来自近1000万个人的2400多万次纵向临床访问的虚拟患者表现.
- 分析了使用异质临床数据的潜空间投影的发育和衰老动态.
主要成果:
- 生命时钟准确地预测了从婴儿期到老年期的所有生命阶段的生物年龄.
- 儿科时钟与儿童发育相关,并预测了营养不良和发育异常等疾病的风险.
- 成年人的时钟与衰老相关,并预测了糖尿病,中风和心血管疾病等与年龄有关的疾病的风险.
结论:
- 生命钟为评估整个生命周期的生物年龄提供了一个统一的框架.
- 该模型区分儿科发育和成人衰老,提供了对健康风险的独特见解.
- 这些发现建立了一个新的方法,通过使用常规的临床数据来推进精确的健康.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K
02:45Biological Clocks and Seasonal Responses
41.5K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.5K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
346
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
346
01:30Pulse rhythm
1.3K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.3K
01:20Lifestyle Factors and Health
406
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
406
01:11Clinical Trials: Overview
4.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.5K