疫情前疾病轨迹和对长期COVID易感性的遗传见解
Natalia Blay1,2,3, Xavier Farré1,2, Judith Garcia-Aymerich4,5,6
1Genomes for Life-GCAT Lab, CORE Program, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
BMC medicine
|October 28, 2025
概括
以前存在的慢性疾病,特别是那些影响精神健康和神经系统的疾病,显著增加患长期COVID的风险. 了解这些疾病的发展轨迹可以帮助识别需要有针对性的预防策略的个人.
科学领域:
- 流行病学 流行病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 长期COVID,以SARS-CoV-2感染后的持续症状为特征,需要进一步调查先前存在的慢性疾病的影响.
- 虽然个别的并发症是已知的风险因素,但连续疾病模式 (轨迹) 对长期COVID发展的影响尚未得到充分研究.
研究的目的:
- 为了确定疫情前疾病轨迹是否会改变长期COVID风险和症状概况.
- 探索共享遗传易感性在长期COVID的发展中的作用.
主要方法:
- 从COVICAT队列 (2020-2023) 中分析了8322名成年参与者.
- 从电子健康记录中重建疫情前 (2010-2019) 疾病轨迹,重点关注常见的两种条件序列.
- 对基因架构和多基因风险评分 (PRS) 的评估,以提高预测能力.
主要成果:
- 38种不同的疾病轨迹与长期COVID的风险增加有关.
- 这些高风险轨迹经常涉及精神/神经障碍,呼吸道疾病和心脏代谢/消化系统问题.
- 没有发现有意义的整体遗传相关性,但神经系统和肌肉骨疾病的PRS显示了与长期COVID风险增加的适度关联.
结论:
- 流行病前的疾病轨迹与长期的COVID风险有显著的关联,具有显著的性别影响.
- 虽然整体遗传联系很弱,但适度的多基因关联表明神经系统和肌肉骨疾病的共同易感性.
- 识别具有高风险多病态轨迹的个体对于有针对性的公共卫生预防和护理战略至关重要.
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