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Updated: May 1, 2026

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
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Published on: March 29, 2017

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中性粒细胞蛋白的二脂肪酸修饰:识别,定位和在NETosis中的作用

Haley L Carlson1,2, Reagan M McGuffee1,2, Rakesh P Patel3

  • 1Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, 63104, USA.

Cell communication and signaling : CCS
|October 28, 2025
PubMed
概括

中性细胞髓氧化酶 (MPO) 产生了修改蛋白质的反应性物种,包括PAD4. 这种由2-chlorohexadecanoic acid (2-ClHA) 进行的修饰激活了PAD4,这是启动中性粒细胞外细胞陷 (NET) 形成的关键步骤.

关键词:
脂类化合物 脂类化合物网症 (NETosis) 是一种疾病.中性粒细胞中性粒细胞.蛋白质修饰是一种蛋白质修饰.

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