相关实验视频
Updated: Jan 13, 2026

11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
12.3K
简单的光谱光度法用于定量分析含有偏醇作为主要成分的两个二元混合物
Karin M Guirguis1, May M Zeid2, Rasha A Shaalan2,3
1Pharmacy Program, Kazan Federal University, Cairo Branch, Cairo, Egypt.
BMC chemistry
|October 28, 2025
概括
简单的光谱光度测量方法可以准确地确定混合物和片中的甲 (PAR) 与甲 (MEL) 和甲 (DOM). 这些可靠的技术为制药分析提供了精确的量化.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
- 频谱光度测量是一种光谱光度测量.
背景情况:
- 在单一剂型中同时确定多种活性药物成分会带来分析挑战.
- 准确的量化对于确保药物疗效和患者安全至关重要.
- 开发简单,可靠和具有成本效益的分析方法对于质量控制至关重要.
研究的目的:
- 开发和验证简单,可靠的光谱光度测量方法,用于混合物I中的甲醇 (PAR) 和甲醇 (MEL) 的同时测定.
- 开发和验证简单,可靠的光谱光学方法,用于在混合物II中同时测定甲醇 (PAR) 和多佩里 (DOM).
- 评估开发的分析程序的绿色性.
主要方法:
- 在PAR-MEL混合物中使用了直接的零顺序光谱和第一顺序导数 (1D) 光谱.
- 使用比例差异方法同时确定PAR和DOM.
- 方法验证是根据ICH标准进行的,包括线性,范围,精度,准确性以及检测和量化的极限.
主要成果:
- 开发的方法显示出极好的线性,在指定度范围内,混合物I的相关系数至少为0.9991,混合物II的相关系数为0.9999.
- 这些方法成功地应用于实验室制造的片剂,产生与报告的方法相比的测试结果.
- 分析程序使用分析生态尺度和AGREE指标对其环境影响进行了评估.
结论:
- 简单可靠的光谱光度法 (零顺序,1D导数和比差) 对于与MEL和DOM同时定量PAR是有效的.
- 经过验证的方法适用于分析散装和制药配方中的这些药物组合.
- 开发的光谱光度仪表程序表现出有利的绿色分析特征.
相关概念视频
Qualitative Analysis
1.3K
Qualitative analysis is the process of identifying elements, ions, or compounds in an unknown sample. It is the first and most fundamental type of analysis based on the hierarchy of analytical goals. This hierarchy is significant as it provides a structured approach to scientific research, with qualitative analysis serving as the initial step, providing essential information before moving on to quantitative or other forms of analysis.
There are two main approaches to qualitative analysis:...
There are two main approaches to qualitative analysis:...
1.3K
Quantitative Analysis
1.3K
Quantitative analysis is a technique for measuring the amount of specific constituents in a sample. When the sample's composition is unknown, qualitative analysis is performed first to identify its components, which ensures that the correct substances are measured during the quantitative phase.
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the...
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the...
1.3K
Flame Photometry: Lab
831
In a flame photometer, when a solution like potassium chloride is aspirated into the flame, the solvent evaporates, leaving behind dehydrated salt. This salt dissociates into free gaseous atoms in their ground state. Some of these atoms absorb energy from the flame, leading to their excitation. The excited atoms return to the ground state, emitting photons at characteristic wavelengths. Because only electronic transitions are involved, the resulting emission lines are very narrow. The intensity...
831
¹H NMR Signal Integration: Overview
3.3K
The intensity of a signal, which can be represented by the area under the peak, depends on the number of protons contributing to that signal. The area under each peak is shown as a vertical line called an integral, with the integral value listed under it, as seen in the proton NMR spectrum of benzyl acetate. Each integral value is divided by the smallest integral value to obtain the ratio of the number of protons producing each signal. The ratio reveals the relative number of protons and not...
3.3K
Spectrophotometry: Introduction
6.6K
Spectrophotometry is the quantitative measurement of the absorption, reflection, diffraction, or transmission of electromagnetic radiation through a material as a function of the intensity and wavelength of the radiation. A spectrophotometer is a device used to measure the change in the radiation intensity caused by its interaction with the material.
The essential components of a spectrophotometer include a source of electromagnetic radiation, a slot for placing a material to be analyzed, and a...
The essential components of a spectrophotometer include a source of electromagnetic radiation, a slot for placing a material to be analyzed, and a...
6.6K
Measuring Reaction Rates
28.6K
Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical...
28.6K

