用化疗治疗的患者中跌倒的危险因素
Shinji Oda1, Kenshi Takechi2, Chiyuki Tsukui1
1Department of Pharmacy, Matsuyama Shimin Hospital, Matsuyama, Japan.
Journal of pharmaceutical health care and sciences
|October 28, 2025
概括
接受化疗的住院患者面临更高的跌倒风险. 将高风险的化疗药物与糖尿病药物结合起来,会显著增加这种风险,需要仔细监测.
科学领域:
- 老年医学 老年医学
- 在瘤学瘤学.
- 患者安全 患者安全
背景情况:
- 跌倒对住院患者构成重大威胁,影响生活质量,增加护理需求.
- 化疗诱导的周围神经病变 (CIPN) 是已知的跌倒风险因素,但其与其他因素的相互作用需要进一步调查.
- 在化疗患者中确定特定的跌倒风险因素对于有针对性的干预措施至关重要.
研究的目的:
- 识别和分析与接受化疗的住院患者中跌倒相关的风险因素.
- 与其他因素相比,确定化疗对跌倒风险的具体贡献.
主要方法:
- 从2016年4月到2023年3月,对21,717名住院患者的回顾性分析.
- 多变量逻辑回归用于确定一般患者群体和化疗小组 (n=443) 中的跌倒风险因素.
主要成果:
- 总体下降率为4.3% (930/21,717). 这是一个很好的数字.
- 化疗成为跌倒的最强的独立风险因素 (OR 3.40).
- 在化疗患者中,关键风险因素包括BMI,认知衰退,低血糖药物,高风险CIPN药物和肺癌.
- 接受低血糖和高风险CIPN药物的患者的跌倒率 (37.5%) 与单独服用 (14.1%) 的患者相比显著更高.
结论:
- 化疗是住院患者中跌倒的独立预测因素.
- 低血糖药物和高风险CIPN药物的组合大大提高了化疗患者的跌倒风险.
- 密切监测下跌风险对于化疗患者至关重要,特别是那些同时服用低血糖和高风险CIPN药物患者.
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