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来自质子疗法中心的三年见解:在表皮瘤治疗规划中发展战略

Lieselotte Lauwens^1,2, Anneleen Goedgebeur^2,3, Tom Boterberg^3,4

¹KU Leuven, University of Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, Belgium.

Technical innovations & patient support in radiation oncology

|October 28, 2025

概括

一种混合质子-光子 (PT-XT) 方法用于后腔膜瘤提供了一个可行的治疗选择. 这种方法表明可接受的大脑干剂量,在选定的患者中没有症状的大脑干损伤.

科学领域:

辐射瘤学辐射瘤学
儿科神经瘤学儿童神经瘤学
医学物理医学物理

背景情况:

用质子疗法 (PT) 治疗后腔膜瘤是具有挑战性的,因为大脑干的近距离和毒性风险.
为这些瘤开发安全有效的辐射策略至关重要.

研究的目的:

评估混合质子-光子 (PT-XT) 方法的可行性和结果,与单独的质子疗法 (PT) 相比,用于内膜瘤,特别是后腔瘤.
评估脑干剂量参数和临床结果,包括症状脑干损伤 (SBI) 和无症状放射性变化 (ARC).

主要方法:

在2020年7月至2023年12月期间接受PT或混合PT-XT治疗的内膜瘤患者的回顾性研究.
治疗方法取决于瘤与大脑干的距离.
在PT和PT-XT组之间比较了剂量计数据和临床结果 (SBI,ARC).

主要成果:

在14名患者中,有9名患者患有后腔膜瘤;5名患者接受混合PT-XT,4名患者仅接受PT.
混合PT-XT方法提供了75%的PT治疗和其余的光子 (XT).
在患者的中位随访时间为22.2个月后,没有观察到有症状的脑干损伤;三名患者有无症状的放射性变化.

结论:

根据瘤的位置和脑干关系,定制的计划方法对于尾瘤治疗至关重要.
在精心选择的患者中,混合PT-XT方法是可行的,可以实现可接受的目标覆盖率和脑干剂量,迄今为止还没有报告有症状的脑干损伤.

关键词:

无症状的放射性变化无症状的放射性变化大脑干损伤的损伤.垂体瘤是什么意思混合计划是一个混合计划.质子疗法是一种质子疗法.治疗计划治疗计划

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