急性登革热感染中的心血管并发症:基于人口的队列研究
Liang En Wee1,2,3, Wei Zhi Tan1, Jo Yi Chow4
1Communicable Diseases Agency, Singapore.
The Lancet regional health. Western Pacific
|October 28, 2025
概括
急性登革热病毒 (DENV) 感染增加了心血管事件的风险,特别是在老年人中. 虽然整体多余负担很小,但在DENV感染后对心脏并发症的监测至关重要.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 登革热病毒 (DENV) 感染,通常是轻微的,与严重的心血管并发症有关.
- 由于DENV发病率上升和心血管事件对发病率的贡献,需要准确估计心脏问题.
研究的目的:
- 为了量化急性DENV感染后心血管事件的负担.
- 与对照组相比,评估DENV感染个体心脏并发症的风险.
主要方法:
- 在新加坡 (2017-2023) 进行的一项基于人口的队列研究包括65,207名DENV感染的成年人和1,616,865名对照.
- 重叠权重平衡共变量,物流回归估计心血管事件的几率高达30天感染后.
主要成果:
- DENV感染显著增加了任何心血管事件 (aOR=10.63),主要心脏不良事件 (aOR=2.92),心律失常 (aOR=18.44) 和缺血性心脏病 (aOR=3.00) 的几率.
- 不同DENV菌株和感染状况之间存在更高的几率,但整体过度负担很小 (<100例中的1例).
- 年龄较大的成年人 (≥60岁) 显示过度负担较高 (100例中有1.25例).
结论:
- 急性DENV感染与30天内心血管事件风险增加有关.
- 老年人需要监测DENV感染后的心脏并发症,因为风险增加.
更多相关视频
06:00Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
Published on: January 26, 2024
2.0K
08:36Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
Published on: November 1, 2018
32.5K
相关概念视频
01:30Acute Coronary Syndrome III: Diagnostic Studies
207
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
207
01:30Coronary Artery Disease III: Clinical Manifestations
317
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
317
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
347
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
347
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
473
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
473
01:26Coronary Artery Disease IV: Preventive Measures
580
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
580
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
256
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
256