预测急诊室访问和老年人死亡率的多药门:加拿大北克的一项基于人口的研究
Alexandre Campeau Calfat1,2,3, Justin P Turner1,4, Marc Simard2
1Faculty of Pharmacy, Université Laval, Québec City, QC, Canada.
概括
药物计数最好预测老年人的紧急诊所和死亡率. 对于公共卫生监测,八种药物的门是一个有用的多药剂措施.
科学领域:
- 老年学是指老年学的学科.
- 药学流行病学 药学流行病学
- 公共卫生 公共卫生
背景情况:
- 多药在老年人中很常见,因此需要更好的临床决策和医疗保健规划工具.
- 确定有效的药物治疗门可以改善社区住户老年人的结果.
- 评估药物的适当性对于管理健康风险至关重要.
研究的目的:
- 评估药物计数和多药物门,以预测老年人频繁的急诊和死亡率.
- 评估不合适性标准 (PIM,抗胆固醇负担,药物相互作用) 对这些结果的预测能力.
- 在分析药物使用预测指标时,比较临床和公共卫生观点.
主要方法:
- 使用北克综合慢性病监测系统进行基于人口的研究.
- 多变量逻辑回归模型用于评估药物使用的预测能力 (AUC).
- 从临床 (包括并发症) 和公共卫生 (不包括并发症) 的角度进行分析.
主要成果:
- 从临床角度来看,药物计数是最有信息的预测指标 (紧急诊所AUC=0.739,死亡率AUC=0.804).
- 公共卫生分析显示,在8种药物中,峰值预测模式是 (AUC=0.690对于紧急诊所,AUC=0.764对于死亡率).
- 不适当性标准的表现并没有超过药物数量或多药物门.
结论:
- 药物计数比预测老年人不良结果的多药门更具有临床信息性.
- 八种药物的门可能是多药监管中有用的公共卫生措施.
- 这些发现可以为临床实践和公共卫生策略提供信息,用于管理多种药物治疗的老年人.
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