母亲有神经性厌食症的儿童的胃肠道发病率:一个纵向队列研究
Nathalie Auger1,2,3,4, Mimi Israël5, Howard Steiger5
1Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.
Psychological medicine
|October 28, 2025
概括
孕产妇神经性厌食症 (AN) 增加了子女患儿胃肠道疾病的风险,包括过度增强的胆管狭窄症和炎症性肠道疾病. 早期干预和支持可以减轻患有AN的母亲生下的孩子的这些风险.
科学领域:
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
- 精神病学是一个精神病学.
背景情况:
- 神经性厌食症 (AN) 可以影响胃肠道 (GI) 的发育和功能.
- 母亲的AN和后代的GI病率之间的关系需要进一步调查.
研究的目的:
- 评估母亲神经性厌食症与后代胃肠道疾病风险之间的关联.
- 为了确定与母亲AN相关的特定儿科胃肠道疾病.
主要方法:
- 北克1,269,370名儿童的纵向队列研究 (2006-2022年).
- 暴露:母亲的神经性厌食症.
- 结果:住院治疗儿科胃肠道疾病 (例如,高性胆道狭窄症,IBD).
- 使用了调整后的考克斯回归模型.
主要成果:
- 母亲的AN与42%的儿童肠道疾病风险增加有关 (HR:1.42,95%CI:1.26-1.61).
- 观察到的显著关联是超性胆道狭窄症 (HR:2.51),炎症性肠病 (HR:2.46) 和直肠出血 (HR:3.46).
- 当母亲在20岁以后发展或涉及多次住院治疗时,后代的风险最高.
结论:
- 母亲性神经性厌食症与儿科胃肠道疾病增加有关.
- 潜在的缓解策略包括心理社会支持,营养康复和母乳养.
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