在结肠镜检查期间用于镇静的普罗波
Garrett Johnson1, George N Okoli2,3, Nicole Askin4
1Department of Surgery, Section of General Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
The Cochrane database of systematic reviews
|October 28, 2025
概括
与传统镇静剂相比,用于结肠镜的普罗波镇静剂可能会提高患者的康复时间和满意度. 虽然通常是安全的,但证据质量很低,需要进一步的研究才能得出关于它的有效性和安全性的最终结论.
科学领域:
- 胃肠病学和肝病学
- 麻醉学和疼痛医学 麻醉学和疼痛医学
- 临床药理学 临床药理学
背景情况:
- 结肠镜是胃肠道疾病的关键诊断和查工具.
- 在结肠镜检查期间,患者的舒适度至关重要,因此需要优化镇静.
- 传统的镇静包括阿片类药物和二类药物,而普罗波福尔则提供了潜在的更深度镇静的替代方案.
研究的目的:
- 为了比较普罗波镇静剂与传统镇静剂 (阿片类药物/类药物) 的疗效和安全性,用于成人结肠镜检查.
- 评估在结肠镜检查期间,麻醉师给药的propofol镇静与非麻醉师给药的镇静的影响.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 在多个数据库 (CENTRAL,PubMed,Embase等) 进行了搜索. 从开始到2024年2月.
- 使用Cochrane的RoB 2工具评估偏差风险和使用GRADE的证据确定性.
主要成果:
- 与传统镇静剂相比,普罗波可以改善恢复时间和患者满意度 (低确定性证据).
- 没有观察到腔输管率或需要使用普罗波进行干预的呼吸事件的显著差异.
- 非麻醉师指导的普罗波在输管和满意度方面显示出与麻醉师指导的普罗波相似的结果,具有潜在的恢复时间益处.
结论:
- 普罗波镇静似乎对结肠镜检查的康复时间和患者满意度有好处,安全性与传统药物相比.
- 普罗波福的益处的证据质量通常很低,这凸显了需要高质量的研究.
- 对于关键的结果,非麻醉学家对普罗波的管理似乎与麻醉学家一样有效,尽管安全性数据有限.
相关概念视频
01:24Parenteral Anesthetics: Overview
570
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
570
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
548
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
548
01:25Endoscopic Procedures II: Colonoscopy
602
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
602
01:24General Anesthesia: Overview
560
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
560
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
502
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
502
01:23Sedatives and Hypnotics: Overview
1.4K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.4K