超声波衍生脂肪分量 (UDFF):美国的一种非侵入性诊断和量化肝硬化症的工具
Alix Sidney1, Marine Roux2, Anita Paisant1,2
1Department of Radiology, CHU Angers, Angers, France.
Journal of clinical ultrasound : JCU
|October 28, 2025
概括
超声波衍生脂肪分数 (UDFF) 显示了量化肝硬化症的中等相关性,超过了中度肝硬化症的CAP. 标准化是其用于管理代谢功能障碍相关的脂肪肝炎 (MASH) 的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 定量超声波检查是什么
背景情况:
- 代谢功能障碍相关的脂肪肝炎 (MASH) 正在上升,增加了准确的肝脏脂肪炎量化需求.
- 新的MASH治疗需要易于使用和具有成本效益的诊断工具.
研究的目的:
- 评估超声波衍生脂肪分数 (UDFF) 用于诊断和量化肝硬化症.
- 将UDFF的性能与MRI衍生的质子密度脂肪分数 (MRI-PDFF) 和肝脏活检进行比较.
- 根据受控衰减参数 (CAP) 评估UDFF.
主要方法:
- 114名患有慢性肝病的患者前性地接受了UDFF和MRI-PDFF.
- 78名患者接受了肝脏活检,104人进行了CAP测量.
- 分析了与MRI-PDFF和活检的相关性,肥胖症诊断的AUC,以及影响UDFF的因素.
主要成果:
- UDFF与MRI-PDFF (r=0.60) 呈现中度至强度的相关性,与活检呈现中度的相关性 (η=0.31).
- 诊断肥胖症的UDFF AUC为0.79 (与MRI-PDFF相比) 和0.82 (与活检相比),超过了2级肥胖症的CAP.
- 与MRI-PDFF相比,UDFF始终高估了5%的肥胖症;表皮厚度>30mm影响了准确性. UDFF没有测量故障.
结论:
- UDFF与MRI-PDFF的相关性中度至强,但结果并不像以前的研究那样高.
- 技术和测量的标准化对于在MASH患者管理中实施UDFF至关重要.
- 由于 UDFF 是一个强大的肝硬化定量化工具,它显示出有前途的前景,在等待方法标准化之前.
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