火病原体与自发妊娠损失的关联:来自巴基斯坦的前性研究
Akmal Zubair1, Ahmed Al-Emam2, Hesham M Hassan3
1Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.
MicrobiologyOpen
|October 28, 2025
概括
TORCH感染,包括Toxoplasma gondii,红疹,细胞巨乳病毒 (CMV) 和简单疹病毒 (HSV),显著增加了孕妇堕胎的风险. 早期检测和管理对于预防不良妊娠结果至关重要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 产科和妇科 产科和妇科
背景情况:
- 火感染是一组先天性感染,可以对胎儿造成重大伤害.
- 了解怀孕期间TORCH感染的患病率对于实施有效的预防策略至关重要.
- 以前的研究表明,TORCH感染与不良妊娠结果 (包括堕胎) 之间存在联系.
研究的目的:
- 在巴基斯坦医学科学研究院 (PIMS) 医院的孕妇中确定TORCH感染 (毒素斑斑淋病,红疹病毒,细胞巨乳病毒和简单疹病毒) 的流行率.
- 调查TORCH感染与不同类型的堕胎 (完整,不完整,错过和受到威胁) 之间的联系.
主要方法:
- 从2021年5月到2022年9月,在PIMS医院进行了一项前性研究,分析了来自孕妇的8000个样本.
- 酶相关免疫吸收试验 (ELISA) 用于检测TORCH病原体的免疫球蛋白M和免疫球蛋白G抗体.
- 使用SPSS (版本 23.0) 进行统计分析,以评估发现的意义 (p < 0.001).
主要成果:
- 在接受研究的孕妇中,有19.82%的孕妇感染了TORCH病原体.
- 毒素菌,红疹病毒,细胞巨乳病毒 (CMV) 和简单疹病毒 (HSV) 个别与各种类型的堕胎有关,具有显著的统计相关性.
- 具体百分比的完整的,不完整的,错过的,和有威胁的堕胎被归因于每个TORCH代理,突出其影响.
结论:
- TORCH感染与孕妇堕胎有显著的相关性,代表了一个主要的病因因素.
- 该研究强调了查孕妇TORCH感染的重要性,以减轻堕胎风险.
- 调查结果强调需要加强产前护理和公共卫生干预措施,以解决巴基斯坦的TORCH感染问题.
相关概念视频
Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...
Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...


