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脂肪衍生干细胞装载的鱼-GelMA/CMC水凝通过抑制巨细胞极化和促进血管生成加速伤口愈合

Xue Xue¹, Han Xue², Rong Lu³

¹Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Journal of biomedical materials research. Part A

|October 28, 2025

概括

这项研究开发了一种鱼皮凝甲酸盐 (F-GelMA) 和甲基纤维素 (CMC) 水凝生物支架. 这种增强的支架,载有脂肪衍生干细胞 (ADSCs),显著加速皮肤伤口愈合和再生.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
组织工程是组织工程.

背景情况:

广泛的皮肤损伤带来了重大的公共卫生和社会经济挑战.
目前的皮肤替代品无法完全复制本地组织结构和功能.
鱼皮衍生的凝甲基酸盐 (F-GelMA) 在机械强度上对皮肤组织工程有局限性.

研究的目的:

使用F-GelMA和碳素甲基纤维素 (CMC) 开发和表征一种新的复合水凝生物支架.
评估F-GelMA/CMC水凝生物支架载有脂肪衍生干细胞 (ADSCs) 的有效性,促进皮肤伤口愈合.

主要方法:

从F-GelMA和CMC制造复合水凝.
物理化学性质的评估:风病学,胀,降解和生物相容性.
在体外评估ADSC装载的水凝生物支架的伤口愈合潜力.

主要成果:

F-GelMA/CMC水凝表现出适合3D细胞外矩阵模拟的物理化学特性.
装有ADSC的F-GelMA/CMC水凝显著增强了伤口再上皮化和原沉积.
生物支架促进了血管生成,角质细胞的增殖和肌纤维细胞沉积,同时减少了炎症.

结论:

复合F-GelMA/CMC水凝为皮肤组织工程提供了一个有前途的生物材料.
装有ADSC的F-GelMA/CMC生物支架有效地加速皮肤伤口愈合和再生.
这种方法为治疗广泛的皮肤损伤提供了潜在的解决方案.

关键词:

脂肪衍生干细胞的基因细胞.碳甲基纤维素的碳甲基纤维素.鱼类凝甲基烯基烯基.重新上皮质化 (re-epithelialization) 的发生伤口修复伤口修复

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