在瘦身与非瘦身代谢功能障碍相关的脂肪性肝病 (MASLD) 中遗传性肝纤维化风险
Kaleb Tesfai1, Luis Antonio Díaz1,2, Juan Pablo Arab2,3
1MASLD Research Center, Division of Gastroenterology and Hepatology, University of California at San Diego, La Jolla, California, USA.
Alimentary pharmacology & therapeutics
|October 28, 2025
概括
瘦身代谢功能障碍相关的脂肪性肝病 (MASLD) 患者表现出与非瘦身MASLD患者相似的显著纤维化风险和遗传风险评分效应. 这表明瘦身的MASLD个体可能面临与超重或肥胖的人相比较的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 遗传学 是一个遗传学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 关于瘦肉代谢功能障碍相关脂肪性肝病 (MASLD) 中肝纤维化风险的数据存在矛盾.
- 了解瘦肉MASLD中的纤维化风险对于准确的患者管理至关重要.
研究的目的:
- 为了比较瘦和非瘦MASLD患者之间的显著纤维化风险.
- 为了确定与纤维化相关的因素在瘦肉的MASLD.
主要方法:
- 对有MASLD的潜在注册成年人进行横截面分析.
- 精瘦和非精瘦MASLD个体的年龄和性别匹配比较.
- 纤维化评估使用过渡性弹性成像,MRI弹性成像和肝脏活检.
- 基因风险评分 (GRS) 的计算,包括PNPLA3,TM6SF2和HSD17B13基因型.
- 在外部拉丁美洲队列中的验证.
主要成果:
- 显著纤维化的患病率在瘦 (27.3%) 和非瘦 (31.1%) MASLD 患者中相似.
- 具有高遗传风险分数 (GRS) 的个体有较高的显著纤维化 (36.5%与25.2%,p=0.043) 的患病率.
- GRS对纤维化患病率的影响在瘦身和非瘦身MASLD组之间是可比的.
结论:
- 与非瘦身MASLD患者相比,瘦身MASLD患者的显著纤维化患病率与非瘦身MASLD患者相似.
- 正如GRS所指出的遗传倾向,在瘦身和非瘦身MASLD中显著影响纤维化风险.
- 不应认为MASLD具有较低的显著肝纤维化风险.
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