可逆化学用于癌症治疗和诊断
Hai Xu1, Hyunsik Hong2, Chowon Kim2
1Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
Chemical reviews
|October 28, 2025
概括
可逆化学为癌症治疗和诊断提供了动态控制. 这些先进的策略可以实现按需治疗,精确向和改善药物输送,以获得更好的患者结果.
科学领域:
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
- 纳米技术 纳米技术
背景情况:
- 可逆化学策略对外部和内部刺激有动态反应,在癌症治疗中比不可逆化学方法具有独特的优势.
- 这些优势包括可持续的功能,有针对性的输送和增强的药物保留,这对于有效的癌症治疗和诊断至关重要.
研究的目的:
- 综合审查癌症治疗和成像的可逆化学策略.
- 探索各种可逆控制机制的多尺度材料的利用.
- 介绍这些策略的应用,优势,挑战和临床潜力.
主要方法:
- 探索用于可逆控制的多尺度材料 (分子,纳米,微,宏).
- 控制机制的分析,包括电子转换,同质化,价值变化,形态变化和机械运动.
- 关于癌症治疗和成像中的应用,优势和挑战的现有文献的审查.
主要成果:
- 可逆策略可以实现按需控制,深度瘤透和长期药物保留.
- 可以将各种可逆控制机制应用于多尺度材料,以满足定制的治疗和诊断功能.
- 临床翻译存在重大潜力,尽管仍然存在挑战.
结论:
- 可逆化学为精确的癌症治疗和早期诊断提供了一个强大的平台.
- 多尺度材料和多种控制机制为先进的癌症护理提供了多功能方法.
- 需要进一步的研究和开发来克服临床挑战,并充分发挥这些创新策略的潜力.
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