单侧非动脉炎前部缺血性视觉神经病变中的周周和黄斑血管变化:一个光学连贯性断层扫描血管学研究
Omar M Said1, Ahmed Ts Saif, Esraa Owis
1Department of Ophthalmology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Indian journal of ophthalmology
|October 28, 2025
概括
光学连贯断层扫描血管造影 (OCTA) 揭示了非动脉炎前部缺血性视神经病变 (NAION) 眼睛的血管密度的逐渐变化. 辐射周毛细血管的变化首先发生,其次是黄斑表面和深层血管密度的减少.
科学领域:
- 眼科医生 眼科 眼科
- 神经眼科神经眼科
- 医疗成像医学成像
背景情况:
- 非动脉炎前部缺血性视神经病变 (NAION) 是视神经损伤的主要原因.
- 了解NAION中微血管变化对于诊断和管理至关重要.
- 光学连贯断层扫描血管造影 (OCTA) 提供了一种非侵入性的方法来可视化视网膜血管结构.
研究的目的:
- 为了评估急性NAION眼中的OCTA发现,与未受影响的同眼相比.
- 描述NAION在发病后最初12周的长度OCTA变化.
- 在急性阶段将OCTA发现与视神经头部相对应.
主要方法:
- 一项前性观察性研究,包括30名单边急性NAION患者.
- 双边的斑点和视神经头部 (ONH) 的OCT和OCTA在基线,6周和12周进行.
- 在不同视网膜层和骨无血管区 (FAZ) 中对血管密度 (VD) 的定量分析.
主要成果:
- 减少神经纤维层厚度 (NFLT) 和团细胞复合体 (GCC) 在NAION眼睛的后分辨率.
- 在所有访问中,NAION眼睛的ONH和周囊血管密度显著下降.
- 黄斑表面血管密度从第二次访问显著下降;深黄斑和FAZ VD显示延迟显著下降.
结论:
- 在NAION中,OCTA揭示了血管变化的时间序列:辐射周,然后是斑点表面,最后是深斑点血管密度.
- 在12周的随访期间,在NAION眼睛中观察到所有测量的OCTA VD生物标志物的逐渐下降.
- 在长时间内,OCTA对NAION中微血管变化的特征有价值.
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