终身休时间体育活动通过减缓表观遗传衰老加速,有益于认知健康:来自大型前性队列研究的结果
Ziyang Ren1, Lirong Nie2, Yuchun Sun2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
Age and ageing
|October 28, 2025
概括
一贯的休时间体育活动 (LTPA) 在一生中,特别是从成年早期开始,显著降低痴呆风险并保持认知功能. 这种持续的活动可能会减缓表观遗传衰老,有助于长期的大脑健康.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 休时间的体力活动 (LTPA) 建议在中年至老年时促进认知健康.
- 然而,对终身LTPA对认知轨迹的长期影响尚不清楚.
研究的目的:
- 调查终身休时间体育活动 (LTPA) 与表观遗传衰老加速 (EAA) 之间的关联.
- 检查LTPA,EAA和老年人纵向认知结果之间的关系.
主要方法:
- 一项前性队列研究,涉及来自健康和退休研究 (HRS) 的9131名参与者.
- 在四个年龄组 (18-29岁,30-39岁,40-49岁,≥50岁) 评估了LTPA.
- 用13个DNA甲基化时钟计算表观遗传年龄加速,并纵向评估认知功能.
主要成果:
- 与较晚出现的LTPA相比,强化或持续活跃的LTPA轨迹的参与者表现出明显较低的痴呆风险.
- 持续活跃的LTPA与从正常认知到认知障碍不痴呆 (CIND) 的进展减少以及更频繁的认知逆转有关.
- 终身LTPA与情节性记忆,定量推理和口语流性更好的表现有关,部分由表观遗传衰老标志物如GrimAge和Zhang Acceleration介导.
结论:
- 从生命早期开始持续的休时间体育活动 (LTPA) 对于减缓表观遗传衰老至关重要.
- 这种LTPA对表观遗传衰老的减缓有助于保持认知健康,特别是在痴呆症症状出现之前.
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