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五秒激光纹理铜表面用于减少子宫内器件中初始铜离子突发释放的铜离子

Junbo Liu¹, Lili Zhou¹, Li Liu¹

¹Women's Health and Obstetrics Center, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, People's Republic of China.

|October 28, 2025

概括

铜子宫内置器 (Cu-IUDs) 由于早期的铜离子释放,可能导致不良子宫反应. 这项研究设计了一个仿生表面以适度释放,改善生物相容性和减少副作用.

科学领域:

生物材料工程生物材料工程
生殖健康技术生殖健康技术
表面科学是一门学科.

背景情况:

铜子宫内装置 (Cu-IUD) 是有效的长期避孕药.
从Cu-IUD中过早,过度释放的铜离子 (Cu2+) 可能导致不良的子宫反应和临床副作用.

研究的目的:

开发Cu-IUD表面修改策略,以控制早期的铜离子释放.
为了提高子宫内器械的铜表面的生物相容性和稳定性.

主要方法:

在铜上制造一个仿生微观结构 (Cu#BM),使用秒激光纹理,灵感来自Epipremnum aureum叶.
在模拟子宫液中评估耐腐蚀性和离子释放特征.
电化学测量,浸泡测试和细胞相容性测试以评估材料稳定性和生物反应.

主要成果:

与未经修改的铜相比,工程化Cu#BM表面表现出增强的耐腐蚀性.
#BM表现出适度的Cu2+释放特征,有效地减轻了最初的爆破释放.
细胞相容性测试证实了改进的铜表面的生物相容性得到了改善.

结论:

五秒激光诱导表面工程是一种可行的方法,可以在铜上创建仿生微观结构.
这种表面修饰有效地抑制了铜中Cu2+的早期爆裂释放,增强了稳定性和生物相容性.
开发的Cu#BM策略具有减少与Cu-IUD相关的临床副作用的翻译潜力.

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