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在黑色素瘤模型中,SPOP抑制剂的分子降解功能增强了STING依赖免疫疗法的疗效

Zhichuan Zhu1,2, Xin Zhou1,3, Max Xu1,3

  • 1Lineberger Comprehensive Cancer Center.

The Journal of clinical investigation
|October 28, 2025
PubMed
概括

小分子SPOP抑制剂通过稳定STING和促进免疫细胞透来增强抗瘤免疫力. 这些抑制剂还作为分子剂,降解CBX4,进一步激活对黑色素瘤的先天免疫反应.

关键词:
细胞生物学 细胞生物学细胞免疫反应的细胞免疫反应.在瘤学瘤学.皮肤癌是一种皮肤癌.乌比奎丁-蛋白质组系统

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