一个贝叶斯框架,用于全基因组的昼夜节律生物标志物检测.
Haocheng Ding1, Lingsong Meng2, Yutao Zhang2
1Department of Biostatistics, Data Science, and Epidemiology, Augusta University, 1120 15th Street, Augusta, 30912 GA, United States.
Briefings in bioinformatics
|October 28, 2025
概括
这项研究引入了BayesCircRhy,这是一种新的贝叶斯方法,用于检测基因表达数据中的昼夜节律. 它提高了识别昼夜基因的准确性和可靠性,这对于了解健康和疾病至关重要.
科学领域:
- 时间生物学 时间生物学
- 基因组学就是基因组学.
- 生物统计学 生物统计学
背景情况:
- 由基因反循环驱动的昼夜节律调节了基本的生理和行为过程.
- 准确检测昼夜生物标志物至关重要,特别是随着OMIC数据集的不断扩大.
- 在转录学中分析昼夜节律的现有方法面临着局限性.
研究的目的:
- 开发一种新的贝叶斯框架,用于在全基因组转录基因组数据中检测昼夜节律.
- 采用错误发现率 (FDR) 方法,将多重测试的先前生物学知识和控制纳入.
- 为昼夜基因识别提供强大而准确的分析工具.
主要方法:
- 开发了一个贝叶斯的等级模型,结合了先前的生物信息.
- 使用反跳马尔科夫链蒙特卡洛 (RJMCMC) 技术进行模型选择.
- 实施了错误发现率 (FDR) 方法,用于多次测试调整.
主要成果:
- 拟议的方法BayesCircRhy在模拟中证明了与竞争方法相比,FDR控制优越.
- 贝叶斯CircRhy表现出对各种错误分布的稳定性,并超过了现有的方法.
- 在人类和小鼠RNA测序数据中得到验证,识别了已知的和新的昼夜基因.
结论:
- BayesCircRhy提供了一个强大而可靠的框架,用于在转录学中检测昼夜节律.
- 该方法增强了昼夜基因的识别,有助于更好地了解健康和衰老.
- 这种贝叶斯式方法为分析复杂的生物节奏提供了有价值的工具.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K
02:45Biological Clocks and Seasonal Responses
41.5K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.5K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
346
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
346