头癌 (化疗) 放射治疗期间营养参数,炎症和免疫生物标志物的动态变化:一项前性的纵向研究
Ying Gu1, Wenyi Lu2, Yiheng Mao2
1Department of Clinical Nutrition, The Second Affiliated Hospital of Soochow University, Sanxiang Road, Suzhou, 215004, China.
概括
接受放射治疗的头癌患者的营养状况显著下降,炎症增加和免疫功能减弱. 早期的营养干预对于在癌症治疗期间管理这些变化至关重要.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 头癌 (HNC) 治疗,包括化疗和放射治疗,显著影响患者的健康.
- 在HNC治疗期间了解营养,炎症和免疫之间的相互作用对于优化患者的治疗结果至关重要.
研究的目的:
- 调查在 (化疗) 放射治疗期间HNC患者营养状况,炎症标志物和免疫生物标志物的动态变化.
- 在整个治疗过程中探索这些参数之间的相关性.
主要方法:
- 对接受 (化疗) 放射治疗的65名HNC患者的前性评估.
- 在四个时间点评估身体成分,营养状况 (NRS2002,PG-SGA),表现状况 (KPS) 和血液学生物标志物:治疗前,治疗中期,治疗结束和治疗后一个月.
- 使用纵向分析和斯皮尔曼相关性来分析变化和关联.
主要成果:
- 在放射治疗期间,许多营养参数 (例如体重,无脂肪质量,肌肉质量,白蛋白,蛋白质摄入量) 和炎症/免疫生物标志物 (例如,白血球,中性粒细胞,淋巴细胞,CRP,IL-6) 发生了显著的时间变化.
- 没有脂肪的质量损失是显著的营养恶化.
- 在放射治疗结束时,营养,炎症和免疫标志物之间发现了显著的相关性.
结论:
- 接受 (化疗) 放射治疗的HNC患者的营养状况逐渐恶化,以无脂肪质量损失为标志.
- 这些营养不足与炎症增加和免疫功能降低有关.
- 营养,炎症和免疫状况的多式监测应纳入放射治疗期间的常规HNC护理.
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