Jove
Visualize
联系我们

相关概念视频

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.1K
2.1K
Protein Complex Assembly02:41

Protein Complex Assembly

2.5K
2.5K
Protein Complex Assembly02:41

Protein Complex Assembly

16.6K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.6K
Molecular Models02:00

Molecular Models

43.5K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.5K
Newman Projections02:06

Newman Projections

20.3K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
20.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Multifunctional Wearable OLED-OPD System with Wavelength-Tunable Emission for Phototheranostics.

ACS sensors·2026
Same author

Synthesis of 3-desoxycollinoketone B and its ability to reduce Alzheimer-associated misfolded proteins.

Nature communications·2026
Same author

A Highly Sensitive Photoplethysmography Sensor Enabled by a Highly Transparent Micromesh OLED Fabricated via an In Situ Mask Evaporation Process.

ACS applied materials & interfaces·2026
Same author

Riemannian denoising model for molecular structure optimization with chemical accuracy.

Nature computational science·2026
Same author

Engineering Excited States of Pt-Based Deep-Blue Phosphors to Enhance OLED Stability.

ACS omega·2025
Same author

BInD: Bond and Interaction-Generating Diffusion Model for Multi-Objective Structure-Based Drug Design.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 13, 2026

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

1.1K

金属基因:用于多种协调复合体的自动化3D调整器生成.

Kyunghoon Lee1,2, Shinyoung Park1, Minseong Park1

  • 1Department of Chemistry, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

Journal of chemical information and modeling
|October 28, 2025
PubMed
概括

MetalloGen为协调复合体生成精确的3D对应器,克服现有方法的局限性. 这种计算化学工具增强了对无机和有机金属系统的基于结构的建模.

科学领域:

  • 计算化学的计算化学
  • 无机化学 无机化学
  • 有机金属化学 有机金属化学

背景情况:

  • 符合生成对于计算化学至关重要,但由于其复杂性,对协调复合体具有挑战性.
  • 现有的方法缺乏灵活性和可靠性,用于各种协调几何形状,连接体和立体化学.

研究的目的:

  • 介绍MetalloGen,这是一个用于单核协调复合体自动化3D符合生成的新算法.
  • 解决当前处理多hapto配体和复杂立体化学的工具的局限性.

主要方法:

  • MetalloGen接受SMILES字符串或分子图形作为输入.
  • 算法基于精选的实验数据 (剑桥结构数据库),MOR41基准集和催化反应进行基准测试.
  • 性能被评估为几何准确性,真实性和立体化学控制.

主要成果:

  • 在所有测试组中,MetalloGen成功地以高准确度重现了适当的几何形状.
  • 证明了强大的立体化学控制,包括对具有多个多合体连接体的具有挑战性的病例.
  • 对于复杂的系统,它始终在性能上优于传统的适应器发电机.

结论:

更多相关视频

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K
Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
09:30

Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps

Published on: July 19, 2024

2.0K

相关实验视频

Last Updated: Jan 13, 2026

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

1.1K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K
Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
09:30

Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps

Published on: July 19, 2024

2.0K
  • MetalloGen提供了一个多功能和可靠的解决方案,用于协调复杂的适应器生成.
  • 提高无机和有机金属化学计算调查的准确性和效率.
  • 为具有挑战性的化学系统提供先进的基于结构的建模和属性预测.