慢性感染作为黑色素瘤侵略性的催化剂:洞察瘤微环境调节的洞察力
Layza Sá Rocha1, Ana Cristina Jacobowski1, Eduarda Thiburcio Do Nascimento Reis1
1Laboratory of Protein Purification and their Biological Functions, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande-MS, Brazil.
Asian Pacific journal of cancer prevention : APJCP
|October 28, 2025
概括
慢性微生物感染加剧了黑色素瘤的攻击性和对治疗的抵抗力. 抗微生物 (AMP) 通过调节瘤微环境,有望控制感染并改善黑色素瘤治疗.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 皮肤黑色素瘤是一种具有高转移潜力的侵袭性皮肤癌.
- 慢性微生物感染越来越多地被认为会影响黑色素瘤的进展和治疗耐药性.
- 瘤微环境中的病原体相互作用可以促进免疫逃避和上皮-介质细胞过渡 (EMT).
研究的目的:
- 调查慢性感染在黑色素瘤攻击性中的作用.
- 评估抗微生物 (AMP) 作为黑色素瘤的潜在治疗策略.
主要方法:
- 进行了对2020-2025年同行评审研究的系统审查.
- 搜索的数据库包括PubMed,Scopus,科学网和谷歌学者.
- 数据合成的重点是微生物物种,抗菌素耐药性 (AMR),AMP有效性,细胞因子,免疫通路和生物信息学.
主要成果:
- 特定的病原体 (例如,金黄色菌,P. aeruginosa,C. tropicalis) 通过炎症和EMT恶化黑色素瘤.
- 抗菌素耐药性 (AMR) 复杂化了治疗,特别是在免疫受损的个体.
- 抗微生物 (AMP) 具有双重抗微生物和免疫调节作用,人工智能驱动的设计增强了特异性和安全性.
结论:
- 慢性微生物感染显著影响黑色素瘤的攻击性和耐治疗性.
- 抗微生物 (AMP) 是一种有前途的多功能方法来治疗黑色素瘤.
- 将AMP与免疫疗法结合使用可能会改善患者的治疗结果,这需要进一步的临床研究.
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