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模仿瘤微环境的支架用于体内恶性瘤模型

Elisabetta Rosellini¹, Maria Grazia Cascone¹

¹Department of Civil and Industrial Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy.

Biomimetics (Basel, Switzerland)

|October 28, 2025

概括

三维 (3D) 仿生支架为癌症研究提供先进的体外模型,通过模仿瘤微环境 (TME) 来改善药物查,改进了传统方法.

科学领域:

生物材料科学生物材料科学
癌症生物学癌症生物学
组织工程是组织工程.

背景情况:

瘤微环境 (TME) 对癌症的进展和耐药性至关重要.
传统的二维和动物模型缺乏精确预测治疗结果的复杂性.
基于脚手架的3D模型为癌症研究提供了一个更具生理相关性的平台.

研究的目的:

提供基于脚手架的体外3D模型以模拟TME的全面审查.
讨论仿生脚手架的特性和制造技术.
突出针对个性化癌症治疗的TME建模的进展和未来方向.

主要方法:

对TME基于脚手架的3D体外模型的文献综述.
自然,合成和混合生物材料支架的分析.
讨论制造技术,如电和3D生物打印.
重点在于结合血管和树皮组成部分.

主要成果:

生物仿真支架可以复制TME的关键特征,如组成,刚性和多孔性.
先进的制造技术可以精确地复制瘤组织的几何和机制.
细胞组件的集成增强了TME复杂性的回顾.

结论:

基于脚手架的3D模型比传统的研究TME的方法有了显著的进步.
标准化和可重复的模型对于临床前药物查和个性化医学至关重要.
需要进一步的研究才能充分利用这些模型在癌症治疗开发中的潜力.

关键词:

在体外3D瘤模型.生物模拟架构 - 生物模拟架构脱细胞化的细胞外矩阵.瘤微环境是一个微环境.

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