来自生物灵感状聚合物的pH响应纳米凝与疏水植入物用于有效的口服输送
Qinglong Liu1, Dewei Ma1, Haoze Cheng1
1Research Institute for Biomaterials, Tech Institute for Advanced Materials Bioinspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing 210037, China.
Gels (Basel, Switzerland)
|October 28, 2025
概括
新的pH响应纳米凝通过改善细胞吸收和保护胃中的药物来增强口服药物输送. 这些纳米载体显示出治疗肠道疾病的前景.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 纳米技术纳米技术
背景情况:
- 口服药物输送面临胃部降解和细胞吸收不良的挑战,限制治疗疗效.
- 现有的pH响应纳米凝与有效的膜相互作用作斗争,阻碍了它们的性能.
- 自然的膜定机制启发了新型纳米载体系统的设计.
研究的目的:
- 设计和合成响应pH的状聚合物,以增强胃肠道药物输送.
- 调查疏水性修饰 (基链长度和接种密度) 对纳米凝特性和性能的影响.
- 评估这些纳米凝在治疗肠道疾病时作为疏水化疗药物的载体的潜力.
主要方法:
- 通过将不同长度 (C10,C14,C18) 和密度 (10-30%) 的类胺接种到聚氨酸 (L-lysine isophthalamide) 骨干上来合成状阳性聚合物.
- 形成的pH响应纳米凝用于加载camptothecin,一种疏水性化疗剂.
- 纳米凝的特征包括pH响应性行为,膜相互作用,药物释放动力学,细胞吸收和对结直肠癌细胞的细胞毒性.
主要成果:
- 基链长度和接种密度显著调节了纳米凝的特性和药物释放.
- 最佳配方 (PLP移植30%C14) 呈现出高药物负载,稳定性和受控释放 (pH1.2时7%;pH7.4时78%超过24小时).
- 纳米凝表现出增强的细胞吸收,细胞质递送,以及对癌细胞的强有力的细胞毒性.
结论:
- 疏水性修饰对于开发有效的口服纳米载体至关重要.
- 设计的响应pH的纳米凝为口服药物输送提供了一个有前途的平台,特别是对于肠道疾病.
- 这种方法增强了药物保护,释放和细胞输送,改善了治疗结果.
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