COVID-19对普遍瘤查,转诊率和在安全网大学医院癌症遗传咨询的出席率的影响
Dimitrios N Varvoglis1,2, Kelsey R Landrum1, Lydia H Comer1
1Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Current oncology (Toronto, Ont.)
|October 28, 2025
概括
在结直肠癌患者中,针对林奇综合征的普遍瘤查在COVID-19大流行期间保持一致. 然而,癌症遗传咨询的出席率低于最佳水平,患者的可及性是关键障碍.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 建议在结直肠癌 (CRC) 患者中对林奇综合征 (LS) 进行全方位瘤查 (UTS).
- COVID-19 流行病可能影响了医疗保健和患者获得遗传服务的机会.
研究的目的:
- 评估COVID-19大流行对CRC患者LS的UTS过程的影响.
- 确定UTS途径中的漏洞和需要改进的领域.
主要方法:
- 在2018-2022年期间,对342名接受切除的CRC患者进行了回顾性队列研究.
- 分析UTS绩效 (IHC/MSI),转诊癌症遗传咨询 (CGC),出席率,以及不出席的原因.
- 患者被分为流行前,流行早期和流行后期的队列.
主要成果:
- 在所有时期中,UTS查率 (MMR IHC) 仍然很高 (93-96%).
- 癌症遗传咨询推率各不相同 (60-71%),出席率低于最佳 (23-36%的非出席率).
- 调度员无法接触患者是不出席的主要原因.
结论:
- 在CRC中,COVID-19大流行并没有显著地扰乱LS的UTS初始阶段.
- 亚最佳癌症遗传咨询的使用仍然存在,突出显示患者可及性是关键障碍.
- 需要进一步的研究来解决医生转诊障碍,并改善患者的安排和推广.
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